Peptide Science research editorial team.
Pentapeptide-18 (Leuphasyl) 200mg Topical Overview
Pentapeptide-18 (Leuphasyl) 200mg Topical from Peptide Science is the synthetic enkephalin-derived pentapeptide with the sequence Tyr-D-Ala-Gly-Phe-Leu, supplied as a topical research formulation for in-vitro neuronal and dermal cell-culture work. The compound is studied alongside Argireline and SNAP-8 in the SNARE-adjacent cosmetic-research signal-peptide subset.
Compound Class and Mechanism
Leuphasyl is structurally based on the leucine-enkephalin pentapeptide (with a D-alanine substitution at position 2 for metabolic stability), originally derived from the proenkephalin neurotransmitter precursor. Preclinical research has characterised the peptide for activity at enkephalin-receptor pathways in cell-culture models, with reported effects on adenylate cyclase modulation upstream of catecholamine release. The compound is studied in dermal-cell research as part of multi-peptide signal-peptide combinations targeting SNARE-complex and neurotransmitter-adjacent pathways. Browse the broader cosmetic peptide range for related signal peptides studied in dermal-cell research.
Specifications
| Property | Value |
|---|---|
| Compound | Leuphasyl (Pentapeptide-18, sequence Tyr-D-Ala-Gly-Phe-Leu) |
| Class | Synthetic enkephalin-derived pentapeptide; SNARE-adjacent signal peptide |
| Amino-acid count | 5 |
| Molecular weight | approximately 583.7 g/mol |
| Source-protein basis | Met-enkephalin (preproenkephalin-derived endogenous pentapeptide) |
| Supplied form | Topical research formulation |
| Strength | 200 mg per supply |
| Purity | greater than 99 percent (HPLC verified) |
| Storage | 2 to 8 degrees Celsius; protect from light |
For the SNARE-complex signal peptide most directly comparable to Leuphasyl, see Argireline 200mg Topical and SNAP-8 200mg Topical.
Handling and Reconstitution
The topical research formulation is supplied for in-vitro cell-culture and animal-model dermatology work, not as a finished cosmetic product. The working concentration used in any given research protocol is set by the principal investigator. Aliquoting reconstituted stock for single-use storage is the standard handling practice for short signal peptides where repeated freeze-thaw cycles can affect activity.
Quality and Shipping
Each batch passes HPLC at greater than 99 percent purity, with mass-spectrometry identity confirmation. A Certificate of Analysis accompanies every order. Material is prepared in a US laboratory under ISO 9001:2015-aligned quality systems and dispatched in insulated, light-protected packaging via overnight or two-day courier.
For laboratory research and development use only. Not for human or veterinary consumption. Has not been evaluated by the U.S. Food and Drug Administration and is not intended to diagnose, treat, cure, or prevent any disease. Purchasers acknowledge they are qualified researchers age 21 or older and accept responsibility for compliance with all applicable federal, state, and local laws.
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