Peptide Science research editorial team.
Acetyl Hexapeptide-3 (Argireline) 200mg Topical Overview
Acetyl Hexapeptide-3 (Argireline) 200mg Topical from Peptide Science is the standard topical research format of the synthetic 6-amino-acid signal peptide derived from the N-terminus of the SNAP-25 protein, supplied for in-vitro neuronal and dermal cell-culture work. The 200 mg supply is the format most cited in preclinical SNARE-complex research.
Compound Class and Mechanism
Argireline (sequence Ac-Glu-Glu-Met-Gln-Arg-Arg-NH2) is the acetylated and amidated 6-residue N-terminal fragment of the synaptosomal-associated protein 25 kDa (SNAP-25), one of the three core components of the SNARE complex that drives synaptic vesicle fusion. The peptide has been characterised in preclinical research for competitive inhibition of SNARE-complex assembly in cell-culture models, which is the structural basis for its study in dermal-cell research alongside related cosmetic signal peptides Leuphasyl and SNAP-8. Browse the broader cosmetic peptide range.
Specifications
| Property | Value |
|---|---|
| Compound | Argireline (Acetyl Hexapeptide-3, also designated Acetyl Hexapeptide-8) |
| Class | Synthetic SNARE-complex signal peptide; cosmetic research compound |
| Amino-acid count | 6 |
| Molecular weight | approximately 888.9 g/mol |
| Supplied form | Lyophilised powder, sealed vial |
| Strength | 200 mg per vial |
| Purity | greater than 99 percent (HPLC and mass-spec verified) |
| Storage | 2 to 8 degrees Celsius lyophilised; minus 20 degrees Celsius long-term |
For related cosmetic signal peptides studied alongside Argireline, see Leuphasyl 200mg and SNAP-8 200mg.
Reconstitution and Handling
The lyophilised vial reconstitutes with bacteriostatic water at the working concentration set by the principal investigator. Aliquoting reconstituted stock for single-use frozen storage is the standard preclinical handling practice cited in peptide-research literature.
Quality and Shipping
Each batch passes HPLC at greater than 99 percent purity, with mass-spectrometry identity confirmation against the theoretical molecular weight. A Certificate of Analysis accompanies every order. Material is filled in a US laboratory under ISO 9001:2015-aligned quality systems and dispatched in temperature-monitored insulated packaging via overnight or two-day courier.
For laboratory research and development use only. Not for human or veterinary consumption. Has not been evaluated by the U.S. Food and Drug Administration and is not intended to diagnose, treat, cure, or prevent any disease. Purchasers acknowledge they are qualified researchers age 21 or older and accept responsibility for compliance with all applicable federal, state, and local laws. Lyophilised vials store at 2 to 8 degrees Celsius; protect from light.
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