Peptide Science research editorial team.
AICAR 50mg Overview
AICAR 50mg from Peptide Science is the synthetic adenosine monophosphate analog (5-Aminoimidazole-4-carboxamide ribonucleotide), supplied as a lyophilised powder for in-vitro AMP-activated protein kinase (AMPK) activation research. AICAR is one of the most-cited research tools in published AMPK-pathway and cellular-energy-stress literature.
Compound Class and Mechanism
AICAR is converted intracellularly to its active form ZMP (AICAR monophosphate, the AMP-mimetic), which allosterically activates AMP-activated protein kinase (AMPK) by mimicking the low-energy AMP signal that AMPK normally senses. Activated AMPK then triggers a cascade of energy-conserving and energy-producing pathways: phosphorylation of acetyl-CoA carboxylase to inhibit fatty acid synthesis, activation of PGC-1-alpha to drive mitochondrial biogenesis, and stimulation of glucose uptake via GLUT4 translocation. The compound is the standard pharmacological AMPK activator in preclinical metabolic-pathway research. Browse the broader anti-aging research range.
Specifications
| Property | Value |
|---|---|
| Compound | AICAR (5-Aminoimidazole-4-carboxamide ribonucleotide) |
| Class | Adenosine analog; AMPK-activator research compound |
| Amino-acid count | n/a |
| Molecular weight | approximately 338.2 g/mol |
| Supplied form | Lyophilised powder, sealed vial |
| Strength | 50 mg per vial |
| Purity | greater than 99 percent (HPLC and mass-spec verified) |
| Storage | Room temperature, sealed, dry; long-term storage at minus 20 degrees Celsius |
For paired research with the mitochondrial-derived peptide MOTS-c which also engages the AMPK pathway, see MOTS-c 10mg.
Reconstitution and Handling
The lyophilised vial reconstitutes with bacteriostatic water at the working concentration set by the principal investigator. Aliquoting reconstituted stock for single-use frozen storage is the standard preclinical handling practice cited in peptide-research literature.
Quality and Shipping
Each batch passes HPLC at greater than 99 percent purity, with mass-spectrometry identity confirmation against the theoretical molecular weight. A Certificate of Analysis accompanies every order. Material is filled in a US laboratory under ISO 9001:2015-aligned quality systems and dispatched in temperature-monitored insulated packaging via overnight or two-day courier.
For laboratory research and development use only. Not for human or veterinary consumption. Has not been evaluated by the U.S. Food and Drug Administration and is not intended to diagnose, treat, cure, or prevent any disease. Purchasers acknowledge they are qualified researchers age 21 or older and accept responsibility for compliance with all applicable federal, state, and local laws.
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