Peptide Science research editorial team.
FOX04-DRI 10mg (Proxofim) Overview
FOX04-DRI 10mg (Proxofim) from Peptide Science is the synthetic 48-amino-acid retro-inverso D-amino-acid peptide designed to disrupt the FOXO4-p53 protein-protein interaction in senescent cells, supplied as a lyophilised vial for in-vitro and preclinical senolytic research. The compound is one of the most-cited research tools in published cellular-senescence and aging-pathway literature.
Compound Class and Mechanism
FOX04-DRI (also designated Proxofim) is the retro-inverso D-amino-acid analog of the FOXO4 protein D-Tri-Foxo4 binding sequence, engineered for resistance to enzymatic degradation. In senescent cells, the FOXO4 transcription factor binds p53 and prevents the apoptotic clearance of damaged cells; FOX04-DRI competitively disrupts this binding, restoring p53-mediated apoptotic clearance of senescent cells in cell-culture models. The peptide is studied as a research tool for senescence-clearance pathway investigation and is the founding member of the small molecule peptide-class senolytics. Browse the broader anti-aging peptide range.
Specifications
| Property | Value |
|---|---|
| Compound | FOX04-DRI (Proxofim, retro-inverso D-amino-acid FOXO4-p53-interaction inhibitor) |
| Class | Senolytic research peptide; FOXO4-p53 disruptor |
| Amino-acid count | 48 |
| Molecular weight | approximately 5232 g/mol |
| Supplied form | Lyophilised powder, sealed vial |
| Strength | 10 mg per vial |
| Purity | greater than 99 percent (HPLC and mass-spec verified) |
| Storage | 2 to 8 degrees Celsius lyophilised; minus 20 degrees Celsius long-term |
For paired research with other mitochondrial-derived and cellular-bioenergetics peptides, see Humanin 10mg or MOTS-c 5mg.
Reconstitution and Handling
The lyophilised vial reconstitutes with bacteriostatic water at the working concentration set by the principal investigator. Aliquoting reconstituted stock for single-use frozen storage is the standard preclinical handling practice cited in peptide-research literature.
Quality and Shipping
Each batch passes HPLC at greater than 99 percent purity, with mass-spectrometry identity confirmation against the theoretical molecular weight. A Certificate of Analysis accompanies every order. Material is filled in a US laboratory under ISO 9001:2015-aligned quality systems and dispatched in temperature-monitored insulated packaging via overnight or two-day courier.
For laboratory research and development use only. Not for human or veterinary consumption. Has not been evaluated by the U.S. Food and Drug Administration and is not intended to diagnose, treat, cure, or prevent any disease. Purchasers acknowledge they are qualified researchers age 21 or older and accept responsibility for compliance with all applicable federal, state, and local laws.
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