FOXO4-DRI 10mg (Proxofim) is a cell-permeable D-retro-inverso peptide from Peptide Sciences, studied as a senolytic agent in ageing research.
FOXO4-DRI and Senescent Cells
In senescent cells, the FOXO4 protein binds p53 and keeps the cells alive. FOXO4-DRI is designed to disrupt this interaction, which in a widely cited 2017 mouse study caused senescent cells to undergo apoptosis while sparing healthy cells. It is a key tool in senolytic research.
FOXO4-DRI 10mg Specifications
| Property | Value |
|---|---|
| Compound | FOX04-DRI (Proxofim, retro-inverso D-amino-acid FOXO4-p53-interaction inhibitor) |
| Class | Senolytic research peptide; FOXO4-p53 disruptor |
| Amino-acid count | 48 |
| Molecular weight | approximately 5232 g/mol |
| Supplied form | Lyophilised powder, sealed vial |
| Strength | 10 mg per vial |
| Purity | greater than 99 percent (HPLC and mass-spec verified) |
| Storage | 2 to 8 degrees Celsius lyophilised; minus 20 degrees Celsius long-term |
Using the 10mg Vial
Suitable for senescence assays and animal ageing models.
Research Considerations
Senolytic studies with FOXO4-DRI commonly measure senescent-cell clearance in aged or chemotherapy-treated mice, along with markers of tissue function such as fur density and renal parameters.
Quality Control, COA and Shipping
Our release testing covers purity (HPLC), identity (MS) and appearance for every production lot. Orders include the lot-matched COA and leave our US warehouse in insulated, tamper-evident packaging to keep research material stable.
Related Research Compounds
Researchers working with FOXO4-DRI often compare results with these catalog compounds:
- OS-01 (100mg x 30 Capsules)
- Humanin 10mg
- SS-31 25mg
- Longevity, Performance & Obesity Research (60 Capsules)
Explore the full Anti Aging Peptides collection, browse the complete Peptide Sciences research peptide catalog, or review published literature on FOXO4-DRI in PubMed.
Research use only. This product is sold strictly for in-vitro laboratory research and development by qualified professionals. It is not for human or veterinary use, not a drug, food or cosmetic, and has not been evaluated by the FDA to diagnose, treat, cure or prevent any disease. Buyers must be 21+ and comply with all applicable laws.
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