Peptide Science research editorial team.
Syn-Coll 200mg (Palmitoyl Tripeptide-5) Topical Overview
Syn-Coll 200mg (Palmitoyl Tripeptide-5) Topical from Peptide Science is the synthetic palmitoylated tripeptide derived from a TGF-beta-activating sequence of thrombospondin-1, supplied as a topical research formulation for in-vitro collagen-pathway research. The compound is studied for TGF-beta receptor pathway activation in dermal fibroblast cell-culture models.
Compound Class and Mechanism
Syn-Coll is the palmitoylated form of a 3-residue thrombospondin-1-derived sequence (Lys-Val-Lys) that has been characterised for activation of latent TGF-beta in cell-culture models. The palmitoyl conjugation provides lipophilic skin-cell penetration. Preclinical research has documented downstream TGF-beta receptor-pathway effects on collagen-I and collagen-III synthesis in cultured fibroblasts, distinguishing the compound mechanistically from the procollagen-fragment-derived Matrixyl. Browse the broader cosmetic peptide range for related signal peptides studied in dermal-cell research.
Specifications
| Property | Value |
|---|---|
| Compound | Syn-Coll (Palmitoyl Tripeptide-5, sequence Pal-Lys-Val-Lys) |
| Class | Synthetic palmitoylated tripeptide; TGF-beta-pathway signal peptide |
| Amino-acid count | 3 |
| Molecular weight | approximately 624.9 g/mol |
| Source-protein basis | Thrombospondin-1 sequence-derived tripeptide (palmitoyl-conjugated form) |
| Supplied form | Topical research formulation |
| Strength | 200 mg per supply |
| Purity | greater than 99 percent (HPLC verified) |
| Storage | 2 to 8 degrees Celsius; protect from light |
For the related palmitoylated procollagen-fragment-derived signal peptide that targets collagen synthesis via a different upstream mechanism, see Matrixyl 200mg Topical.
Handling and Reconstitution
The topical research formulation is supplied for in-vitro cell-culture and animal-model dermatology work, not as a finished cosmetic product. The working concentration used in any given research protocol is set by the principal investigator. Aliquoting reconstituted stock for single-use storage is the standard handling practice for short signal peptides where repeated freeze-thaw cycles can affect activity.
Quality and Shipping
Each batch passes HPLC at greater than 99 percent purity, with mass-spectrometry identity confirmation. A Certificate of Analysis accompanies every order. Material is prepared in a US laboratory under ISO 9001:2015-aligned quality systems and dispatched in insulated, light-protected packaging via overnight or two-day courier.
For laboratory research and development use only. Not for human or veterinary consumption. Has not been evaluated by the U.S. Food and Drug Administration and is not intended to diagnose, treat, cure, or prevent any disease. Purchasers acknowledge they are qualified researchers age 21 or older and accept responsibility for compliance with all applicable federal, state, and local laws.
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